Title:
SYNTHESIS OF PLATINUM COMPLEX
Document Type and Number:
Japanese Patent JP3022264
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To produce a platinum complex useful for a raw material of a carcinostatic agent, etc., in high yield by adjusting a specific cis-[ diaquo(trans-1- cyclohexanediamine)platinum (II)] compound to a specific pH value with an alkali solution of an oxalic acid to react them.
SOLUTION: cis-[Diaquo(trans-1-cyclohexanediamine)platinum(II)] expressed by formula I (the configuration of 1,2-cyclohexanediamine is a trans-1 isomer) is made to react with oxalic acid or an oxalic acid derivative to synthesize cis-[oxalato(trans-1-1,2cyclohexanediamine)platinum(II)] expressed by formula II (the configuration of 1,2-cyclohexanediamine is a trans-1 isomer; R is formula III, formula IV, etc.). In this process, the reaction system is adjusted to pH 3.0-6.0 with an alkali solution while oxalic acid or an oxalic acid derivative is added. This enables the production of a platinum complex, useful as a raw material for producing a carcinostatic agent, in high yield.
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Inventors:
Junichi Taniuchi
Chihiro Nakanishi
Chihiro Nakanishi
Application Number:
JP20914995A
Publication Date:
March 15, 2000
Filing Date:
July 25, 1995
Export Citation:
Assignee:
Devio Farm S.A.
International Classes:
C07F15/00; (IPC1-7): C07F15/00
Attorney, Agent or Firm:
Daisuke Tanaka