付加環化反応を含む、レニン阻害剤の合成

Title:

付加環化反応を含む、レニン阻害剤の合成

Document Type and Number:

Japanese Patent JP2009509990

Kind Code:

A

Abstract:

The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III, wherein R, R 1 , and R' are as defined in the specification, or a salt thereof, and a compound of formula IV wherein R, R 1 , R 2 and R' are as defined in the specification, and processes of manufacturing these.

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Inventors:

Stuart John Mickel
Wolfgang Marteller

Application Number:

JP2008532650A

Publication Date:

March 12, 2009

Filing Date:

September 26, 2006

Export Citation:

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Assignee:

NOVARTIS AG

International Classes:

C07C249/02; C07C231/12; C07C237/20; C07C251/24; C07D207/08; C07D207/16; C07D405/04; A61K31/165; A61P9/12; A61P43/00; C07D307/33

Attorney, Agent or Firm:

Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi

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