To provide a method for synthesizing taxol or its derivative having a tumor suppression effect.
An intermediate for the taxol expressed by formula (11) (R1 is H, hydroxy, a protected hydroxy or -OCOR30, or forms carbonate together with R2; R2 is H, hydroxy, a protected hydroxy, oxo or -OCOR31, or forms carbonate together with R1; R3 is H, hydroxy, a protected hydroxy or -OCOR32; R7b is H, an alkyl, cyano, hydroxy, a protected hydroxy or -OCOR36; R7c is H, an alkyl, an alkenyl, an alkynyl, an aryl or a heteroaryl; R9 is H, hydroxy, a protected hydroxy, oxo or -OCOR33, or forms carbonate together with R10; and R10 is H, hydroxy, a protected hydroxy, oxo or -OCOR29, or forms carbonate together with R9) or the like and a method for synthesizing the intermediate are provided, respectively.
SOMOZA CARMEN
KIM HYEONG B
SHINDO MITSURU
BIEDIGER RONALD J
BOATMAN P DOUGLAS
SMITH CHASE
LIANG FENG
MURTHI KRISHNA
Yasuo Shibata