Title:
SYNTHETIC METHOD OF β-LACTAM
Document Type and Number:
Japanese Patent JP3726121
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide the synthetic method of a β-lactam in the presence of high-temperature and high-pressure water, and a manufacturing method of the β lactam.
SOLUTION: This synthetic method of the β-lactam is characterized in that the β-lactam is synthesized by reacting a β-amino acid in the presence of high- temperature and high-pressure water. In this case, characteristically, β-lactam is rapidly synthesized by cyclizing the β-amino acid under the condition that the water temperature is 200°C or higher and the water pressure is 10 MPa or higher. The manufacturing method of the β-lactam is characterized in that the β-lactam is synthesized by reacting the β-amino acid in the presence of the high-temperature and high-pressure water and then separated and purified with a separating agent for column separation.
Inventors:
Kiyotaka Hatada
Osamu Sato
Mitsuo Kanakubo
Yutaka Ikushima
Kazuo Torii
Osamu Sato
Mitsuo Kanakubo
Yutaka Ikushima
Kazuo Torii
Application Number:
JP2000389408A
Publication Date:
December 14, 2005
Filing Date:
December 21, 2000
Export Citation:
Assignee:
National Institute of Advanced Industrial Science and Technology
International Classes:
C07D205/08; C07D201/08; (IPC1-7): C07D201/08; C07D205/08
Domestic Patent References:
| JP57159758A | ||||
| JP58144367A | ||||
| JP499473B1 | ||||
| JP4710715B1 | ||||
| JP4631539B1 |
Attorney, Agent or Firm:
Masahiko Sudo