Title:
生体高分子繊維を含んでなる合成多層構造
Document Type and Number:
Japanese Patent JP2010504122
Kind Code:
A
Abstract:
The invention relates to a method for the in vitro preparation of a synthetic multi-layer structure comprising biopolymer fibers, wherein the biopolymer fibers in each layer are unidirectionally oriented, which comprises successive polymerisation of layers of a biopolymer fiber forming solution in the presence of a magnetic field. Advantageously, the fiber orientation in at least one layer differs from that in at least one of its superior and/or inferior layer according to an angle alpha. The invention also relates to a biological tissue-like multi-layer structure comprising the synthetic multi-layer structure and cells inoculated therein, such as an orthogonal multi-layer collagen tissue-like cornea, and the method for its preparation. The invention may be used for preventing or treating a damaged tissue, or for creating a model for biological testing, such as pharmacotoxicity testing.
Inventors:
James, Torbet
David, John, Stuart, Humes
David, John, Stuart, Humes
Application Number:
JP2009528716A
Publication Date:
February 12, 2010
Filing Date:
September 19, 2007
Export Citation:
Assignee:
Centre National De La Recherche Scientifique (C.N.R.S)
International Classes:
A61L27/00; A61K35/12; A61P27/02; B32B5/12; B32B5/26; D01F4/00
Foreign References:
| WO2004050134A2 | 2004-06-17 |
Other References:
JPN6012045668; ＢＩＯＰＯＬＹＭＥＲＳ ＶＯＬ．２３, 1984, Ｐ．１２６１-１２６７
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota