合成トリテルペノイドおよび疾患の治療における使用方法

Japanese Patent JP4923146

B2

The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.

Spawn michael
Libby Cullen
Gribble Gordon W.
Honda Tadashi
Clar Robert M.
Meyer Colin Jay.

JP2010542411A

April 25, 2012

January 12, 2009

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Riata Pharmaceuticals, Inc.
Trustees of Dartmouth College

A61K31/275; A61K47/32; A61K47/38; A61P13/12; C07J63/00

JP2005314381A

YETES,MS. et al,Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes,Molecular Cancer Therapeutics,2007年,Vol.6,p.154-162
LIBY,K. et al,The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling ,Cancer Research,2005年,Vol.11,p.4789-4798
高橋徹 他,臓器障害におけるストレス蛋白の役割,ストレス蛋白Heme Oxygenase-1(HO-1)の腎及び腸管保護作用,2006年,Vol.30,p.359-365
高橋徹 他,酸化ストレスに対するヘムオキシゲナーゼ-1の臓器保護的役割,日薬雑誌,2007年,Vol.130,p.252-256

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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