Title:
試料中の標的細胞をエンリッチするシステムおよび方法
Document Type and Number:
Japanese Patent JP6924210
Kind Code:
B2
Abstract:
A system for enriching target cells in a sample is disclosed. The system comprises a microfluidic chip comprising a sample inlet, a sample outlet, a waste outlet and a microfluidic channel, the sample inlet being coupled to an upstream end of the microfluidic channel and the sample outlet and the waste outlet being coupled to a downstream end of the microfluidic channel, the microfluidic chip being configured such that target cells are directed to the sample outlet and non-target cells are directed to the waste outlet; a sample input pump configured to introduce the sample into the sample inlet of the microfluidic chip; an output flow rate detector configured to measure a flow rate at the sample outlet and/or the waste outlet of the microfluidic chip; a sample collection switching valve having a configuration switchable between a first configuration in which the sample output of the microfluidic chip is coupled to a sample output container and a second configuration in which the sample output of the microfluidic chip is coupled to a waste output container; and a controller configured to control the configuration of the sample collection switching valve using the flow rate measured by the output flow rate detector.
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Inventors:
Bagut, Ali Asgar S.
Wu, Andrew En-two
Jun Kuang, fan
Guan, Guophon
Chao, Shutse
Kaw, Youruon
Lee, Efan
Leon, Man Chun
Wu, Andrew En-two
Jun Kuang, fan
Guan, Guophon
Chao, Shutse
Kaw, Youruon
Lee, Efan
Leon, Man Chun
Application Number:
JP2018557005A
Publication Date:
August 25, 2021
Filing Date:
May 04, 2016
Export Citation:
Assignee:
Biolidics Limited
International Classes:
C12M1/00; C12N5/09; C12Q1/02; C12Q1/6827; C12Q1/6841; C12Q1/6851; C12Q1/686; C12Q1/6869; G01N33/48; G01N33/68; G01N37/00
Domestic Patent References:
| JP2015524674A | ||||
| JP2001503681A |
Foreign References:
| US20150226657 | ||||
| WO2015057159A1 | ||||
| WO2016010861A1 | ||||
| WO2015002975A1 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito