Ｔ細胞レセプター

Japanese Patent JP6956164

B2

The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted FMNKFIYEI (158-166) peptide epitope derived from α Fetoprotein (AFP). Certain preferred TCRs of the invention demonstrate excellent binding characteristics and specificity profiles for this AFP epitope. T cell receptors of the invention comprise at least one TCR alpha chain variable domain and/or at least one TCR beta chain variable domain, the alpha chain variable domain comprising an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1- 112 of SEQ ID No: 2, and/or the beta chain variable domain comprising an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1- 112 of SEQ ID No: 3.

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Molloy, Peter
Bread free, nicholas

JP2019219695A

October 27, 2021

December 04, 2019

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Adaptimmune Limited

C12N15/12; A61K35/17; A61K35/76; A61K38/17; A61K45/00; A61K47/64; A61K48/00; A61P35/00; C07K14/725; C12N1/15; C12N1/19; C12N1/21; C12N5/10

J. Immunother., (2008), 31, [3], p.246-253

Shintaro Nogawa
Shinji Kai
Yusuke Kaneko
Kiyoshi Inamoto
Masami Tomita

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