Title:
ＴＧＦベータスーパーファミリーホモ多量体およびその使用
Document Type and Number:
Japanese Patent JP7159148
Kind Code:
B2
Abstract:
The present invention discloses heterodimers comprising endoglin-Fc and ALKI-Fc, or hetero dimers comprising endoglin-Fc and ALK2-Fc. The Fe domains can include amino acid mutations that promote heterodimer formation. In certain aspects, the disclosure provides heteromeric polypeptide complexes comprising a co-receptor of the TGF-beta superfamily and an extracellular domain of a type I serine/threonine kinase receptor of the TGF beta superfamily, an extracellular domain of a type II serine/threonine kinase receptor of the TGF-beta superfamily, or an additional co-receptor of the TGF-beta superfamily. In some embodiments, the disclosure provides heteromultimers comprising a ligand-domain of one or more co-receptor selected from: endoglin, Cripto-1, Cryptic, Cryptic family protein IB, CRIMI, CRIM2, BAMBI, BMPER, RGM-A, RGMB, hemojuvelin, betaglycan, and MuSK. In some embodiments, the disclosure provides soluble heteromultimers comprising a ligand-domain of a co-receptor and a ligand-binding domain of a type II receptor selected from: ActRIIA, ActRIIB. TGFBRII, BMPRII, and MISRII. In some embodiments, the disclosure provides soluble heteromultimers comprising a ligand-domain of a co-receptor and a ligand-binding domain of a type I receptor selected from: ALK1, ALK2, ALK3, ALK4, ALK5, ALK6, and ALK7. In certain aspects, such TGF-beta superfamily heteromultimers may be used to regulate (promote or inhibit) growth of tissues or cells including, for example, bone and hematopoietic lineages, including red blood cells.
Inventors:
Kumar, Ravindra
Greenberg, Asha
Sako, Diane S.
Castongie, Rosline
Greenberg, Asha
Sako, Diane S.
Castongie, Rosline
Application Number:
JP2019500446A
Publication Date:
October 24, 2022
Filing Date:
July 06, 2017
Export Citation:
Assignee:
Axelron Pharma Incorporated
International Classes:
C12N15/12; A61K38/17; C07K14/715; C07K19/00; C12N15/62; C12P21/02
Domestic Patent References:
| JP2014510084A |
Foreign References:
| WO2014055869A1 | ||||
| WO2015160940A1 |
Other References:
Molecular Biology of theCell,2015年,vol.26, p.3117-3127
J. Biochem. Mol. Biol.,2011年,vol.286, no.34, p.30034-30046
J. Biochem. Mol. Biol.,2011年,vol.286, no.34, p.30034-30046
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki