Title:
ナノポア検出にとって有用なタグ付きヌクレオチド
Document Type and Number:
Japanese Patent JP7032383
Kind Code:
B2
Abstract:
The present disclosure relates to compounds comprising a negatively-charged polymer moiety which is capable of entering a nanopore and upon entering a nanopore in the presence of positive ions results in an increased flow of the positive ions through the nanopore. The present disclosure provides methods of preparing the compounds and for their use as nanopore-detectable tags, in particular, for nanopore-based nucleic acid detection and sequencing.
Inventors:
Trance, andrew
Gremyachinsky, dormitory
Chrysali, Peter Jay
Bat, ashwini
Gremyachinsky, dormitory
Chrysali, Peter Jay
Bat, ashwini
Application Number:
JP2019510793A
Publication Date:
March 08, 2022
Filing Date:
August 24, 2017
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C08G81/00; C07K2/00; C12N15/09; C12N15/11; C12Q1/6837; C12Q1/6874; C12Q1/6876
Foreign References:
| WO2015148402A1 | ||||
| US20130264207 | ||||
| US20140309144 |
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi