Title:
標的特異的ＣＲＩＳＰＲ変異体
Document Type and Number:
Japanese Patent JP7345563
Kind Code:
B2
Abstract:
The present invention relates to an artificially engineered CRISPR/Cas9 system. More particularly, the present invention relates to an artificially engineered CRISPR enzyme having enhanced target specificity and a use of an artificially engineered CRISPR/Cas9 system including the same enzyme in genome and/or epigenome manipulation or modification, genome targeting, genome editing, and in vitro diagnosis, etc.
Inventors:
Lee Jun Sung
Jung Min Hee
choi yuri
Lee Jung Jun
Jung Min Hee
choi yuri
Lee Jung Jun
Application Number:
JP2021563732A
Publication Date:
September 15, 2023
Filing Date:
April 26, 2019
Export Citation:
Assignee:
TOOLGEN INCORPORATED
International Classes:
C12N9/16; C12N15/55; C12N15/113; C12N15/63; C12N15/86
Foreign References:
| WO2019009682A2 | ||||
| WO2018106727A1 |
Other References:
Lee, J. K. et al.,"Directed evolution ofCRISPR-Cas9 to increase its specificity",Nat. Commun.,2018年,Vol. 9; 3048,pp. 1-10
Slaymaker, I. M. et al.,"Rationally engineered Cas9nucleases with improved specificity",Science,2016年,Vol. 351,pp. 84-88
Slaymaker, I. M. et al.,"Rationally engineered Cas9nucleases with improved specificity",Science,2016年,Vol. 351,pp. 84-88
Attorney, Agent or Firm:
TRY International Patent Attorney Corporation
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