Title:
がん幹細胞がんのための新規な治療及び診断ストラテジーとしてのＯ−アセチル化ＧＤ２ガングリオシドのターゲティング
Document Type and Number:
Japanese Patent JP6735229
Kind Code:
B2
Abstract:
An antibody recognizing the O-acetylated-GD2 ganglioside for the treatment of Cancer Stem Cells (CSC) cancer, a pharmaceutical composition including the antibody for treating a CSC cancer and a method for treating a CSC cancer in a patient in need thereof, the method including administering the antibody to the patient. A method for diagnosing a CSC, the use of the O-acetylated-GD2 ganglioside as a biomarker of CSC cancer, and a method for predicting the response of a subject affected with CSC cancer to a treatment with the antibody or the composition are also described.
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Inventors:
Burkle Stefan
Cochoneau Dennis
Dorvilius Millene
Rudousar Jean-Marc
Terme Michael
Cochoneau Dennis
Dorvilius Millene
Rudousar Jean-Marc
Terme Michael
Application Number:
JP2016509328A
Publication Date:
August 05, 2020
Filing Date:
April 29, 2014
Export Citation:
Assignee:
Aussie Dee 2 Pharma
Universite Donant
Universite Donant
International Classes:
C07K16/30; A61K39/395; A61K45/00; A61P35/00; A61P35/02; A61P35/04; C07K19/00
Domestic Patent References:
| JP2012508384A | ||||
| JP2010539097A | ||||
| JP2013513370A | ||||
| JP2012506255A | ||||
| JP2010505909A |
Foreign References:
| WO2012131564A1 | ||||
| WO2012113266A1 | ||||
| WO2011088123A1 |
Other References:
Clinical Cancer Research, 2009, Vol.15, No.17, pp.5323-5337
Journal of Molecular Signaling, 2011, Vol.6, No.7, pp.1-11
Journal of Molecular Signaling, 2011, Vol.6, No.7, pp.1-11
Attorney, Agent or Firm:
Masayuki Masabayashi
Hayashi Ichiyoshi
Tetsuo Shiba
Iwaike Mitsuru
Hayashi Ichiyoshi
Tetsuo Shiba
Iwaike Mitsuru