Title:
タウＰＥＴ画像化リガンド
Document Type and Number:
Japanese Patent JP6966456
Kind Code:
B2
Abstract:
The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
Inventors:
Morders, Diederick Willem Elizabeth
Rombouts, Frederick Jean Rita
Rinalz, Joseph Elizabeth
Andres-Gill, Jose, Ignacio
Fierence, catrine
Chew packing, Vladimir
Bowmans, Guy Maurits Earl.
De Clark, Leaven Dennis Harwig
Corbes, Harms
Jean way
Rombouts, Frederick Jean Rita
Rinalz, Joseph Elizabeth
Andres-Gill, Jose, Ignacio
Fierence, catrine
Chew packing, Vladimir
Bowmans, Guy Maurits Earl.
De Clark, Leaven Dennis Harwig
Corbes, Harms
Jean way
Application Number:
JP2018540455A
Publication Date:
November 17, 2021
Filing Date:
February 01, 2017
Export Citation:
Assignee:
Janssen Pharmaceuticals N.B.
International Classes:
C07D471/04; A61K51/00
Domestic Patent References:
| JP2012529493A | ||||
| JP2011512354A |
Foreign References:
| US20130343992 | ||||
| WO2015110263A1 |
Other References:
Discovery ofN-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer’s Disease,Journal of Medicinal Chemistry,2017年,60 (4),1272 -1291
Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future,Journal of Medicinal Chemistry,2015年,58 (11),4365 -4382
Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807,Molecular Imaging,2016年,15,1-15
Cai, Lisheng,Chemistry with [18F]Fluoride Ion,European Journal of Organic Chemistry,2008年,(17),2853 -2873
Frydman, Benjamin,Synthesis of substituted 1,5- and 1,7-naphthyridines and related lactams,Journal of Organic Chemistry,1971年,36 (3),450-454
Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future,Journal of Medicinal Chemistry,2015年,58 (11),4365 -4382
Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807,Molecular Imaging,2016年,15,1-15
Cai, Lisheng,Chemistry with [18F]Fluoride Ion,European Journal of Organic Chemistry,2008年,(17),2853 -2873
Frydman, Benjamin,Synthesis of substituted 1,5- and 1,7-naphthyridines and related lactams,Journal of Organic Chemistry,1971年,36 (3),450-454
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori
Uetake Yukiko
Yasuhito Suzuki
Eiji Katayama
Junko Kobayashi
Norio Omori
Uetake Yukiko
Yasuhito Suzuki