Title:
14位で官能化されたタキサン誘導体及びその製造方法
Document Type and Number:
Japanese Patent JP4690039
Kind Code:
B2
Abstract:
A process for the preparation of compounds of formula XIV starting from compounds of formula XIII
wherein
R 2 is an acyl group or an alcohol-protecting group;
R 3 is hydrogen, acyl, alkyl or, taken together with R 4 , forms a C=O, C=S, SO, SO 2 group;
R 4 is hydrogen or, taken together with R 3 , forms a C=O, C=S, SO, SO 2 group;
R 5 is hydrogen or an alcohol-protecting group;
R 6 is aryl, substituted aryl, heteroaryl;
comprising:
a) selective reduction of the azido group to amino group;
b) optional treatment with alkylating or acylating agents;
c) cleavage of the C7 protective group;
d) opening of the oxazolidine.
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Inventors:
Gabriele, Fontana
Bombardelli, Ezio
Battaria, Arturo
Bardelli, Eleonora
Andrea Guellini
Germi, Maria Louisa
Curry, Giacomo
Pokal, Donato
Bombardelli, Ezio
Battaria, Arturo
Bardelli, Eleonora
Andrea Guellini
Germi, Maria Louisa
Curry, Giacomo
Pokal, Donato
Application Number:
JP2004535440A
Publication Date:
June 01, 2011
Filing Date:
September 05, 2003
Export Citation:
Assignee:
Indena Sochieta Pell Ationi
International Classes:
C07D305/14; C07D493/08; C07D497/08; C07D498/06
Domestic Patent References:
| JP8506326A |
Foreign References:
| WO1994022856A1 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda