Title:
抗有糸分裂剤及び抗腫瘍剤としてのタキソイド接合体
Document Type and Number:
Japanese Patent JP2004509919
Kind Code:
A
Abstract:
Compounds according to formula I:wherein T1 is a taxoid group, preferably of Formula II:wherein R1 is C6H5; R2 is O; L is a linking group; and T2 is a substituent selected from the group consisting of epipodophyllotoxin, amsacrine, ellipticine, anthracycline antibiotic, mitoxantrone, and colchicine groups, and pharmaceutically acceptable salts thereof, are provided herein. The compounds are useful in, among other things, treating tumors or cancer in subjects in need thereof, inducing cellular differentiation, and inhibiting cellular mitosis.
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Inventors:
Lee, Kuo-Shun
Sea, Chen
Bastow, Kenneth
One, Hui-Kang
Sea, Chen
Bastow, Kenneth
One, Hui-Kang
Application Number:
JP2002530050A
Publication Date:
April 02, 2004
Filing Date:
September 25, 2001
Export Citation:
Assignee:
University of North Carolina at Chapel Hill
International Classes:
A61K47/48; A61P35/00; A61P43/00; C07D305/14; C07D405/12; C07D471/04; C07D493/04; C07D519/00; C07H15/26; C07H17/02; (IPC1-7): C07D493/04; A61K47/48; A61P35/00; A61P43/00; C07D519/00
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo