Title:
テクネチウム-99m及びレニウムで標識した小型作用剤及び腫瘍の画像化方法
Document Type and Number:
Japanese Patent JP5186075
Kind Code:
B2
Abstract:
The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tumors, e.g., carcinomas, melanomas and other tumors. In another embodiment, the invention relates to methods of imaging tumors using radiolabeled metal complexes. Preferred radiolabeled complexes for imaging tumors include technetium and rhenium complexes. The high tumor uptake and significant tumor/nontumor ratios of the technetium complexes of the invention indicate that such small technetium-99m-based molecular probes can be developed as in-vivo diagnostic agents for melanoma and its metastases. In yet another embodiment, the invention relates to methods of treatment of tumors using a radiolabeled metal complex as a radiopharmaceutical agent to treat the tumor.
Inventors:
Ashfaq Mohamed
Matthew Fribe
Christina Bolzzati
Alan Gee Jones
Alan Devison
Matthew Fribe
Christina Bolzzati
Alan Gee Jones
Alan Devison
Application Number:
JP2001580865A
Publication Date:
April 17, 2013
Filing Date:
April 27, 2001
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
A61K51/00; C07C323/42; A61K31/555; A61K51/04; A61P35/00; C07C323/41; C07C323/58; C07D295/13; C07F13/00; C07K5/06
Domestic Patent References:
| JP62096460A | ||||
| JP61005065A | ||||
| JP2180865A |
Foreign References:
| US5919934 | ||||
| WO1989010759A1 |
Other References:
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Journal of Nuclear Medicine,1987年,Vol.28,No.6,p.1012-1019
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Inorganic Chemistry,1993年,Vol.32,No.14,p.3114-3124
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Journal of Nuclear Medicine,1987年,Vol.28,No.6,p.1012-1019
Applied Radiation and Isotopes,1991年,Vol.42,No.6,p.503-508
Nuclear Medicine and Biology,1989年,Vol.16,No.8,p.805-811
Nuclear Medicine and Biology,1993年,Vol.20,No.1,p.105-115
European Journal of Nuclear Medicine,1993年,Vol.20,No.4,p.302-307
Nuclear Medicine and Biology,1988年,Vol.15,No.2,p.215-223
Inorganic Chemistry,1993年,Vol.32,No.14,p.3114-3124
Nuclear Medicine and Biology,1997年,Vol.24,No.6,p.499-505
Attorney, Agent or Firm:
Norio Saeki