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Title:
組換えT細胞受容体遺伝子を用いて細胞ベースの治療薬を製造するための技法
Document Type and Number:
Japanese Patent JP2021516049
Kind Code:
A
Abstract:
本技術は、概して、組換えT細胞受容体(TCR)ライブラリーを作製するための組成物および方法、ならびにその治療的使用方法に関する。本技術の組成物および方法は、がんおよびウイルス感染症のための個別化標的療法としての、抗原特異的TCRレパートリーの迅速な単離に有用である。

Inventors:
Decoski Brandon
Chang Chen-Yu
Application Number:
JP2020545519A
Publication Date:
July 01, 2021
Filing Date:
February 27, 2019
Export Citation:
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Assignee:
The University of Kansas
International Classes:
C12N15/85; A61K9/107; A61K35/17; A61K38/19; A61K39/395; A61K48/00; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; C12N1/19; C12N1/21; C12N5/071; C12N5/0783; C12N5/0789; C12N5/10; C12N15/12; C12N15/34; C12N15/35; C12N15/37; C12N15/38; C12N15/39; C12N15/40; C12N15/41; C12N15/44; C12N15/45; C12N15/46; C12N15/48; C12N15/49; C12N15/50; C12N15/51; C12N15/86; C12N15/861; C12N15/864; C12N15/867; C12Q1/02; C40B40/08
Foreign References:
WO2017096239A12017-06-08
WO2017053902A12017-03-30
WO2017180738A12017-10-19
WO2017120428A22017-07-13
Other References:
SUN X ET AL.: "“Unbiased analysis of TCRα/β chains at the single-cell level in humanCD8+ T-cell subsets.”", PLOS ONE, vol. 7, no. 7, JPN6023006439, 6 July 2012 (2012-07-06), pages 40386, ISSN: 0004992724
TURCHANINOVA MA ET AL.: "“Pairing of T-cell receptor chainsvia emulsion PCR.”", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 43, no. 9, JPN6023006437, 26 June 2013 (2013-06-26), pages 2507 - 15, XP055392257, ISSN: 0004992725, DOI: 10.1002/eji.201343453
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto