Title:
炎症誘発性媒介物質の産生を減弱することによって神経性障害を処置する技法
Document Type and Number:
Japanese Patent JP2007526022
Kind Code:
A
Abstract:
Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, and brain injury are described. More particularly, TNF blocking agents that target TNF-receptor interactions and the effects of downstream secreted cytokines associated with an inflammatory cascade are described. Such TNF blocking agents are administered directly to the brain by, for example, intraparenchymal administration, intracerebroventricular administration, or administration into a cerebral artery. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject.
Inventors:
Shafer, Lisa El
Application Number:
JP2006536859A
Publication Date:
September 13, 2007
Filing Date:
October 22, 2004
Export Citation:
Assignee:
Medtronic Incorporated
International Classes:
A61M37/00; A61K9/22; A61K38/00; A61K39/395; A61K45/00; A61M5/142; A61P25/00; A61P25/04; A61P25/28; C07K16/24; G01N33/53; A61M5/172; A61M39/02; A61B
Domestic Patent References:
| JP2001515866A | 2001-09-25 | |||
| JP2002542826A | 2002-12-17 | |||
| JP2002537356A | 2002-11-05 |
Foreign References:
| US20030171711A1 | 2003-09-11 | |||
| WO1997042990A1 | 1997-11-20 |
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita