Title:
テロメラーゼ阻害剤
Document Type and Number:
Japanese Patent JP2009533336
Kind Code:
A
Abstract:
The present invention relates to metal complexes of formulae (I), (IIa) or (IIb) which interaction with quadruplex DNA and act as inhibitors of telomerase activity, the synthesis of these complexes and their use in the treatment of cancer.
Inventors:
Bilal, Ramon
Anna Arora, Arnal
Neil, Stephan
Reed, julie
Anna Arora, Arnal
Neil, Stephan
Reed, julie
Application Number:
JP2009503652A
Publication Date:
September 17, 2009
Filing Date:
April 05, 2007
Export Citation:
Assignee:
IMPERIAL INNOVATIONS LIMITED
Fundacio Privada Institut Katara Dinvestigasio Kimika
CANCER RESEARCH TECHNOLOGY LTD.
Fundacio Privada Institut Katara Dinvestigasio Kimika
CANCER RESEARCH TECHNOLOGY LTD.
International Classes:
C07C251/24; A61K31/555; A61P35/00; A61P43/00; C07D471/04; C07F3/06; C07F9/00; C07F15/00; C07F15/04; C12N9/99
Domestic Patent References:
| JPH10167787A | 1998-06-23 | |||
| JPH0649051A | 1994-02-22 | |||
| JPH11507646A | 1999-07-06 | |||
| JP2005509694A | 2005-04-14 | |||
| JPS5139726A | 1976-04-02 |
Foreign References:
| CN1737002A | 2006-02-22 | |||
| CN1687083A | 2005-10-26 | |||
| WO2001002370A1 | 2001-01-11 |
Other References:
DI BELLA, SANTO; FRAGALA, IGNAZIO; LEDOUX, ISABELLE; DIAZ-GARCIA, MARIA A.; MARKS, TOBIN J.: "Synthesis, Characterization, Optical Spectroscopic, Electronic Structure, and Second-Order Nonli", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 119(40), JPN6011069676, 1997, US, pages 9550 - 9557, ISSN: 0002112308
CIRINGH, YANGZHEN; GORDON-WYLIE, SCOTT W.; NORMAN, RICHARD E.; CLARK, GEORGE R.; WEINTRAUB, SUSA: "Multinuclear Paramagnetic NMR Spectra and Solid State X-ray Crystallographic Characterization of", INORGANIC CHEMISTRY, vol. 36(22), JPN6011069678, 1997, US, pages 4968 - 4982, ISSN: 0002112309
LESLIE, KENNETH S.; DRAGO, RUSSELL S.; GRIFFIS, ANDREW B.; HAMILTON, DOROTHY E.; O'CONNOR, CHARL: "Study of the thermodynamics of base and dioxygen binding to the cobalt(II) Schiff base complex C", INORGANIC CHEMISTRY, vol. 26(12), JPN6011069680, 1987, US, pages 1951 - 7, ISSN: 0002112310
ZANELLO, PIERO; CINQUANTINI, ARNALDO: "Electrochemical behavior of a series of N,N'-1,2-phenylenebis(salicylideneiminato) transition me", TRANSITION METAL CHEMISTRY (DORDRECHT, NETHERLANDS), vol. 10(10), JPN6011069681, 1985, NL, pages 370 - 4, ISSN: 0002112311
GRAVERT,DENNIS J., INORGANIC CHEMISTRY, vol. V35 N17, JPN5009003690, 1996, pages 4837 - 4847, ISSN: 0002112312
YANG, GAO-WEN; XIA, XIAO-PING; JIANG, SONG-SHAN; ZHAO, CHENG-XUE: "Synthesis and properties of nickel (II) complexes with Schiff base bearing ω-substituted hexame", HECHENG HUAXUE, vol. 3(1), JPN6011069683, 1995, CN, pages 75 - 9, ISSN: 0002112313
MANDAL, SUBHRANGSU S.; VARSHNEY, UMESH; BHATTACHARYA, SANTANU: "Role of the Central Metal Ion and Ligand Charge in the DNA Binding and Modification by Metallosa", BIOCONJUGATE CHEMISTRY, vol. 8(6), JPN6011069685, 1997, US, pages 798 - 812, ISSN: 0002112314
MANDAL,SUBHRANGSU S., JOURNAL OF INORGANIC BIOCHEMISTRY, vol. V63 N4, JPN5009003686, 1996, pages 265 - 272, ISSN: 0002112315
VERQUIN,GERALDINE, JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, vol. V9 N3, JPN5009003688, 2004, pages 345 - 353, ISSN: 0002112316
BOGHAEI, DAVER M.; MOHEBI, SAJJAD: "Non-symmetrical tetradentate vanadyl Schiff base complexes derived from 1,2-phenylene diamine an", TETRAHEDRON, vol. 58(26),, JPN6011069669, 2002, GB, pages 5357 - 5366, ISSN: 0002112302
SAILAJA, S.; REDDY, M. RADHAKRISHNA; RAJU, K. MOHANA; REDDY, K. HUSSAININDIAN: "Synthesis and characterization of cobalt(II) chelates of N,N'-ethylene bis-salicylaldimine and r", INDIAN JOURNAL OF CHEMISTRY, SECTION A: INORGANIC, BIO-INORGANIC,PHYSICAL, THEORETICAL AND ANALYTICA, vol. 38A(2), JPN6011069670, 1999, IN, pages 156 - 160, ISSN: 0002112303
DI BELLA S, INORGANICA CHIMICA ACTA, vol. V357 N13, JPN5009003691, 1 November 2004 (2004-11-01), pages 3865 - 3870, ISSN: 0002112304
LI, ZHONGHUI; LI, JIANZHANG; LU, XIAOXIA; QIN, SHENGYING: "Synthesis of cosalophen derivatives", HUAXUE YANJIU YU YINGYONG, vol. 12(1), JPN6011069672, 2000, CN, pages 77 - 80, ISSN: 0002112305
LI, JIAN-ZHANG; QIN, SHENG-YING; LI, ZHONG-HUI; YANG, HUA: "Synthesis of crown mono- and bis-Schiff bases and dioxygen affinities of their cobalt(II) comple", HUAXUE XUEBAO, vol. 57(3), JPN6011069673, 1999, CN, pages 298 - 304, ISSN: 0002112306
DI BELLA, SANTO; LEONARDI, NICOLETTA; CONSIGLIO, GIUSEPPE; SORTINO, SALVATORE; FRAGALA, IGNAZIO: "Fluorescent Self-assembled monolayers of bis(salicylaldiminato)zinc(II) Schiff base complexes", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. (23), JPN6011069675, 2004, DE, pages 4561 - 4565, ISSN: 0002112307
CIRINGH, YANGZHEN; GORDON-WYLIE, SCOTT W.; NORMAN, RICHARD E.; CLARK, GEORGE R.; WEINTRAUB, SUSA: "Multinuclear Paramagnetic NMR Spectra and Solid State X-ray Crystallographic Characterization of", INORGANIC CHEMISTRY, vol. 36(22), JPN6011069678, 1997, US, pages 4968 - 4982, ISSN: 0002112309
LESLIE, KENNETH S.; DRAGO, RUSSELL S.; GRIFFIS, ANDREW B.; HAMILTON, DOROTHY E.; O'CONNOR, CHARL: "Study of the thermodynamics of base and dioxygen binding to the cobalt(II) Schiff base complex C", INORGANIC CHEMISTRY, vol. 26(12), JPN6011069680, 1987, US, pages 1951 - 7, ISSN: 0002112310
ZANELLO, PIERO; CINQUANTINI, ARNALDO: "Electrochemical behavior of a series of N,N'-1,2-phenylenebis(salicylideneiminato) transition me", TRANSITION METAL CHEMISTRY (DORDRECHT, NETHERLANDS), vol. 10(10), JPN6011069681, 1985, NL, pages 370 - 4, ISSN: 0002112311
GRAVERT,DENNIS J., INORGANIC CHEMISTRY, vol. V35 N17, JPN5009003690, 1996, pages 4837 - 4847, ISSN: 0002112312
YANG, GAO-WEN; XIA, XIAO-PING; JIANG, SONG-SHAN; ZHAO, CHENG-XUE: "Synthesis and properties of nickel (II) complexes with Schiff base bearing ω-substituted hexame", HECHENG HUAXUE, vol. 3(1), JPN6011069683, 1995, CN, pages 75 - 9, ISSN: 0002112313
MANDAL, SUBHRANGSU S.; VARSHNEY, UMESH; BHATTACHARYA, SANTANU: "Role of the Central Metal Ion and Ligand Charge in the DNA Binding and Modification by Metallosa", BIOCONJUGATE CHEMISTRY, vol. 8(6), JPN6011069685, 1997, US, pages 798 - 812, ISSN: 0002112314
MANDAL,SUBHRANGSU S., JOURNAL OF INORGANIC BIOCHEMISTRY, vol. V63 N4, JPN5009003686, 1996, pages 265 - 272, ISSN: 0002112315
VERQUIN,GERALDINE, JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, vol. V9 N3, JPN5009003688, 2004, pages 345 - 353, ISSN: 0002112316
BOGHAEI, DAVER M.; MOHEBI, SAJJAD: "Non-symmetrical tetradentate vanadyl Schiff base complexes derived from 1,2-phenylene diamine an", TETRAHEDRON, vol. 58(26),, JPN6011069669, 2002, GB, pages 5357 - 5366, ISSN: 0002112302
SAILAJA, S.; REDDY, M. RADHAKRISHNA; RAJU, K. MOHANA; REDDY, K. HUSSAININDIAN: "Synthesis and characterization of cobalt(II) chelates of N,N'-ethylene bis-salicylaldimine and r", INDIAN JOURNAL OF CHEMISTRY, SECTION A: INORGANIC, BIO-INORGANIC,PHYSICAL, THEORETICAL AND ANALYTICA, vol. 38A(2), JPN6011069670, 1999, IN, pages 156 - 160, ISSN: 0002112303
DI BELLA S, INORGANICA CHIMICA ACTA, vol. V357 N13, JPN5009003691, 1 November 2004 (2004-11-01), pages 3865 - 3870, ISSN: 0002112304
LI, ZHONGHUI; LI, JIANZHANG; LU, XIAOXIA; QIN, SHENGYING: "Synthesis of cosalophen derivatives", HUAXUE YANJIU YU YINGYONG, vol. 12(1), JPN6011069672, 2000, CN, pages 77 - 80, ISSN: 0002112305
LI, JIAN-ZHANG; QIN, SHENG-YING; LI, ZHONG-HUI; YANG, HUA: "Synthesis of crown mono- and bis-Schiff bases and dioxygen affinities of their cobalt(II) comple", HUAXUE XUEBAO, vol. 57(3), JPN6011069673, 1999, CN, pages 298 - 304, ISSN: 0002112306
DI BELLA, SANTO; LEONARDI, NICOLETTA; CONSIGLIO, GIUSEPPE; SORTINO, SALVATORE; FRAGALA, IGNAZIO: "Fluorescent Self-assembled monolayers of bis(salicylaldiminato)zinc(II) Schiff base complexes", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. (23), JPN6011069675, 2004, DE, pages 4561 - 4565, ISSN: 0002112307
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma