Title:
TEMPERATURE RESPONSE-TYPE IN VIVO DEGRADABLE POLYMER
Document Type and Number:
Japanese Patent JP3832970
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a polymer which is degraded in vivo in response to plural pieces of vital information (an enzyme and a temperature).
SOLUTION: The objective polymer consists of a water soluble polymer having a three-dimensional network structure wherein a temperature-responsible polymer is introduced, as a graft chain, into an in vivo degradable polymer or a polymer having an in vivo degradable site in the molecule. As this polymer, of poly(N-isopropylacrylamide), polyacrylamide, polydimethylacrylamide, copolymers thereof, or a block copolymer of polyethylene glycol and polypropylene glycol are cited.
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Inventors:
Nobuhiko Yui
Application Number:
JP12797998A
Publication Date:
October 11, 2006
Filing Date:
May 11, 1998
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
A61K9/00; C08G81/00; A61K47/32; A61K47/34; A61K47/36; A61K47/42; C08F251/00; C08F291/00; (IPC1-7): C08G81/00; C08F251/00; C08F291/00; //A61K9/00; A61K47/32; A61K47/34; A61K47/36; A61K47/42
Domestic Patent References:
| JP9012651A | ||||
| JP8231435A | ||||
| JP3056543A | ||||
| JP8041212A | ||||
| JP6116169A | ||||
| JP4108827A | ||||
| JP5117385A | ||||
| JP8502082A | ||||
| JP9169850A | ||||
| JP64058303A |
Foreign References:
| WO1995032219A1 |
Attorney, Agent or Firm:
Toshio Nishizawa
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