Title:
エストロゲン受容体調節剤としての四環状複素化合物
Document Type and Number:
Japanese Patent JP2005513133
Kind Code:
A
Abstract:
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and / or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and / or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
Inventors:
Lameille M
The Jayne, Naresyu Kumar Ev
Nugu, Raymond
Sui, Zihua
Sue, The Eye
The Jayne, Naresyu Kumar Ev
Nugu, Raymond
Sui, Zihua
Sue, The Eye
Application Number:
JP2003554693A
Publication Date:
May 12, 2005
Filing Date:
December 02, 2002
Export Citation:
Assignee:
Ortho-McNeill Pharmacy Incorporated
International Classes:
C07D311/58; A61K31/37; A61K31/4025; A61K31/4523; A61K31/453; A61K31/5377; A61K31/55; A61K45/00; A61P3/06; A61P9/00; A61P13/08; A61P15/00; A61P15/18; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; C07D311/64; C07D313/18; C07D493/04; C07F7/08; C07F7/18; (IPC1-7): C07F7/08; A61K31/37; A61K31/4025; A61K31/4523; A61K31/453; A61K31/5377; A61K31/55; A61K45/00; A61P3/06; A61P9/00; A61P13/08; A61P15/00; A61P15/18; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; C07D311/58; C07D311/64; C07D313/18; C07D493/04; C07F7/18
Attorney, Agent or Firm:
Heikichi Odashima