Title:
テトラヒドロ葉酸合成酵素遺伝子
Document Type and Number:
Japanese Patent JP4634302
Kind Code:
B2
Abstract:
By finding a novel tetrahydrofolate synthetase gene and a protein encoded by said gene, a method for identifying a compound which inhibits cell growth accelerating activity of said protein is provided, and a judging method, a preventing method and a treating method of colon cancer are provided. A DNA comprising a nucleotide sequence of from the 94th to 2934th positions of the nucleotide sequence of SEQ ID NO:1 of the SEQUENCE LISTING; a polynucleotide which specifically hybridizes with said DNA; a protein encoded by said DNA; a recombinant vector comprising said DNA; a transformant comprising said recombinant vector; an antibody for said protein; a method for producing said protein; a method for identifying a compound which inhibits cell growth accelerating activity possessed by said protein; a method for judging colon cancer, characterizing in that expressed amount of said DNA is measured; a kit for judging colon cancer; a preventive agent and/or therapeutic agent for colon cancer.
Inventors:
Takeyuki Sugiura
Application Number:
JP2005514328A
Publication Date:
February 16, 2011
Filing Date:
September 30, 2004
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
C12N15/09; A61K31/00; A61P1/00; A61P35/00; C12N1/15; C12N1/19; C12N1/21; C12N9/00; C12N9/10; C12Q1/527; C12Q1/68; G01N33/50; G01N33/53; G01N33/574
Domestic Patent References:
| JP2006517788A | 2006-08-03 | |||
| JP2006517094A | 2006-07-20 | |||
| JP2005006658A | 2005-01-13 |
Foreign References:
| WO2001075067A2 | 2001-10-11 | |||
| WO2001057190A2 | 2001-08-09 | |||
| WO2002083873A2 | 2002-10-24 |
Attorney, Agent or Firm:
Shohei Oguri
Hironori Honda
Toshimitsu Ichikawa
Hironori Honda
Toshimitsu Ichikawa