Title:
癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン
Document Type and Number:
Japanese Patent JP2008529989
Kind Code:
A
Abstract:
The invention relates to compounds of formula I, wherein Ra is —C(O)OR1, in which R1 is 1-7C-alkyl, 3-7C-cycloalkyl, or 1-7C-alkyl substituted by one to four substituents independently selected from R2, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and either Q is optionally substituted by Rba and/or Rbb and/or Rbc, and is phenyl or naphthyl, or Q is optionally substituted by Rca and/or Rcb, and is Har, or Q is optionally substituted by Rda and/or Rdb, and is Het, or Q is optionally substituted by Rea and/or Reb, and is 3-7C-cycloalkyl, which are useful for the therapy of hyperproliferative diseases, in particular human cancer.
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Inventors:
Claus Pekari
Matthias Schmidt
Thomas Behr
Thomas beckers
Björn Bartels
Matthias Schmidt
Thomas Behr
Thomas beckers
Björn Bartels
Application Number:
JP2007553625A
Publication Date:
August 07, 2008
Filing Date:
February 08, 2006
Export Citation:
Assignee:
Nycomed GmbH
International Classes:
C07D495/04; A61K31/282; A61K31/337; A61K31/4365; A61K31/444; A61K31/4745; A61K31/475; A61K31/506; A61K31/513; A61K31/519; A61K31/5377; A61K31/675; A61K31/704; A61K31/7048; A61K31/7068; A61K33/24; A61K38/00; A61K38/21; A61K45/00; A61P31/18; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| JP2002506072A | 2002-02-26 |
Foreign References:
| WO2002092076A1 | 2002-11-21 | |||
| WO2005033102A2 | 2005-04-14 |
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Hiroshi Sugimoto
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard
Reinhard Einsel
Toshiomi Yamazaki
Takuya Kuno
Hiroshi Sugimoto
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard
Reinhard Einsel