Title:
抗腫瘍剤としてのテトラロン誘導体
Document Type and Number:
Japanese Patent JP4091431
Kind Code:
B2
Abstract:
The present invention provides compounds of formula I and pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, X and Y have the meanings defined in the specification. The compounds have histone deacetylase (HDAC) inhibitory activity which is useful in cancer treatment. Also provided is a process for making a compound of formula I by reacting a compound of formula III with a compound of formula IV wherein A is a displaceable group and PG is a protecting group.
Inventors:
Georges, Guy
Grossman, Adelbert
The Telkaw, Tim
Schaeffer, Wolfgang
Ulrich, Tibes
Grossman, Adelbert
The Telkaw, Tim
Schaeffer, Wolfgang
Ulrich, Tibes
Application Number:
JP2002547883A
Publication Date:
May 28, 2008
Filing Date:
December 06, 2001
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61P35/00; A61K31/165; C07C259/06; A61K31/166; A61K31/235; A61P35/02; A61P43/00; C07D213/50; C07D295/116
Domestic Patent References:
| JP10182583A | ||||
| JP2000503012A |
Foreign References:
| WO1998055449A1 | ||||
| WO1998024759A1 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama