アポトーシスシグナル調節キナーゼ１阻害剤を含むテトラゾール及びその使用方法

Title:

アポトーシスシグナル調節キナーゼ１阻害剤を含むテトラゾール及びその使用方法

Document Type and Number:

Japanese Patent JP7328254

Kind Code:

B2

Abstract:

The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof:which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

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Inventors:

Wang, Guochen
Shen, Rui Chao
Granger, Bullet
F, Chin
Shin, Xue Chao
Hye, yon
Ron, Chang
Ma, Chun
One, bottle
Oru, Yat, Sun

Application Number:

JP2020560343A

Publication Date:

August 16, 2023

Filing Date:

May 01, 2019

Export Citation:

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Assignee:

Enanta Pharmaceuticals Incorporated

International Classes:

C07D401/14; A61K31/444; A61K31/4545; A61K31/497; A61K31/5355; A61P1/00; A61P1/04; A61P1/16; A61P3/00; A61P3/04; A61P3/10; A61P7/00; A61P7/02; A61P7/06; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P23/02; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D407/14; C07D409/14; C07D413/14; C07D417/14

Domestic Patent References:

JP2012532931A
JP2012514024A
JP2016540029A
JP2013530240A
JP2016503801A

Foreign References:

US20130203731
WO2008016131A1
CN107793400A

Attorney, Agent or Firm:

Patent Attorney Corporation Asamura Patent Office

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