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Title:
TEXAPHYRIN-PLATINUM(IV) CONJUGATE AND COMPOSITION FOR USE IN OVERCOMING PLATINUM RESISTANCE
Document Type and Number:
Japanese Patent JP2021102616
Kind Code:
A
Abstract:
To provide a novel compound capable of being used for treating platinum-resistant cancer cell line.SOLUTION: The present disclosure provides compounds of formula (I), or an oxidized metal complex, a pharmaceutically acceptable salt, an organometallic isomer, or a tautomer thereof. [R1 and R2 are each independently H, halo, hydroxy or the like; A1 and A2 are each independently H, halo, hydroxy or the like; Y1 to Y4 are each independently H, halo, alkyl or the like; and X1 to X6 are each independently H, hydroxy, halo, amino, platinum(IV) chelating group or the like; wherein at least one of X1 to X6 is the platinum(IV) chelating group.SELECTED DRAWING: Figure 1

Inventors:
JONATHAN L SESSLER
JONATHAN ARAMBULA
ZAHID H SIDDIK
GREGORY THIABAUD
Application Number:
JP2021032438A
Publication Date:
July 15, 2021
Filing Date:
March 02, 2021
Export Citation:
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Assignee:
BOARD OF REGENTS UNIV OF TEXAS SYSTEM
International Classes:
C07F15/00; A61K9/08; A61K9/10; A61K9/12; A61K9/127; A61K9/72; A61K31/28; A61K31/282; A61K31/285; A61K31/295; A61K31/30; A61K31/32; A61K31/337; A61K31/409; A61K31/513; A61K31/675; A61K31/704; A61K31/7048; A61K33/24; A61K33/242; A61K33/243; A61K33/244; A61K33/26; A61K33/34; A61K33/36; A61K38/14; A61K45/00; A61K47/20; A61K47/22; A61K47/24; A61K47/54; A61P1/00; A61P15/00; A61P35/00; A61P35/02; A61P43/00; C07F5/00; C07F19/00
Domestic Patent References:
JP2017519004A2017-07-13
JP2002516878A2002-06-11
Foreign References:
WO2001032211A22001-05-10
Other References:
JONATHAN F. ARAMBULA ET AL., DALTON TRANSACTIONS, vol. 48, JPN7022000637, 2009, pages 10834 - 10840, ISSN: 0004900212
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto