Title:
TEXAPHYRIN-PLATINUM(IV) CONJUGATE AND COMPOSITION FOR USE IN OVERCOMING PLATINUM RESISTANCE
Document Type and Number:
Japanese Patent JP2021102616
Kind Code:
A
Abstract:
To provide a novel compound capable of being used for treating platinum-resistant cancer cell line.SOLUTION: The present disclosure provides compounds of formula (I), or an oxidized metal complex, a pharmaceutically acceptable salt, an organometallic isomer, or a tautomer thereof. [R1 and R2 are each independently H, halo, hydroxy or the like; A1 and A2 are each independently H, halo, hydroxy or the like; Y1 to Y4 are each independently H, halo, alkyl or the like; and X1 to X6 are each independently H, hydroxy, halo, amino, platinum(IV) chelating group or the like; wherein at least one of X1 to X6 is the platinum(IV) chelating group.SELECTED DRAWING: Figure 1
Inventors:
JONATHAN L SESSLER
JONATHAN ARAMBULA
ZAHID H SIDDIK
GREGORY THIABAUD
JONATHAN ARAMBULA
ZAHID H SIDDIK
GREGORY THIABAUD
Application Number:
JP2021032438A
Publication Date:
July 15, 2021
Filing Date:
March 02, 2021
Export Citation:
Assignee:
BOARD OF REGENTS UNIV OF TEXAS SYSTEM
International Classes:
C07F15/00; A61K9/08; A61K9/10; A61K9/12; A61K9/127; A61K9/72; A61K31/28; A61K31/282; A61K31/285; A61K31/295; A61K31/30; A61K31/32; A61K31/337; A61K31/409; A61K31/513; A61K31/675; A61K31/704; A61K31/7048; A61K33/24; A61K33/242; A61K33/243; A61K33/244; A61K33/26; A61K33/34; A61K33/36; A61K38/14; A61K45/00; A61K47/20; A61K47/22; A61K47/24; A61K47/54; A61P1/00; A61P15/00; A61P35/00; A61P35/02; A61P43/00; C07F5/00; C07F19/00
Domestic Patent References:
| JP2017519004A | 2017-07-13 | |||
| JP2002516878A | 2002-06-11 |
Foreign References:
| WO2001032211A2 | 2001-05-10 |
Other References:
JONATHAN F. ARAMBULA ET AL., DALTON TRANSACTIONS, vol. 48, JPN7022000637, 2009, pages 10834 - 10840, ISSN: 0004900212
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto