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Patent Searching and Data


Title:
THERAPEUTIC AGENT FOR HEPATITIS
Document Type and Number:
Japanese Patent JPH0859476
Kind Code:
A
Abstract:

PURPOSE: To provide a new saponin compound exhibiting excellent hepatopathy- suppressing action and low side effects and useful as an agent for the treatment of hepatitis.

CONSTITUTION: This agent is composed of the compound of formula I. The compound of formula I can be produced by extracting the rhizome of HANASUGE with hot 50% methanol, distilling out the methanol, suspending the residue in water, successively fractionating with dichloromethane, ethyl acetate and 1-butanol, concentrating the obtained 1-butanol fraction, fractionating by silica gel column chromatography and purifying the obtained compound of formula II by preparative high-performance liquid chromatography. The compounds of formula I and formula II are active components for the treating agent for hepatitis and the administration dose is 10-500mg/day by oral administration and 5-500mg/day by parenteral administration based on 1kg of the body weight.


Inventors:
SAITO SADAO
NAGAMURA YOICHI
Application Number:
JP19662294A
Publication Date:
March 05, 1996
Filing Date:
August 22, 1994
Export Citation:
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Assignee:
SHIRATORI PHARM
International Classes:
C07H15/256; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61K36/896; A61P1/16; C07J73/00; (IPC1-7): A61K31/70; C07J73/00
Attorney, Agent or Firm:
Miyuki Ariga (3 outside)