Title:
THERAPEUTIC BENZAMIDE COCRYSTALS
Document Type and Number:
Japanese Patent JP2023063281
Kind Code:
A
Abstract:
To provide cocrystals of 3-{[5-(azetidine-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide (hereafter called "benzamide" ) for treating or preventing a T-cell mediated auto-immune disease, disorder or condition.SOLUTION: The invention provides: cocrystals of 3-{[5-(azetidine-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide selected from a 1:1 benzamide fumaric acid cocrystal, a 1:1 benzamide maleic acid cocrystal, a 1:1 benzamide malonic acid cocrystal, a 1:1 benzamide L-tartaric acid hydrate cocrystal, and a 1:1 benzamide gentisic acid cocrystal; and pharmaceutical compositions comprising the cocrystals.SELECTED DRAWING: None
Inventors:
ALEX EBERLIN
CHRISTOPHER FRAMPTON
JOANNE HOLLAND
CHRISTOPHER FRAMPTON
JOANNE HOLLAND
Application Number:
JP2022176753A
Publication Date:
May 09, 2023
Filing Date:
November 02, 2022
Export Citation:
Assignee:
CONDUIT UK MAN LTD
International Classes:
C07D403/14; A61K31/497; A61P1/04; A61P1/16; A61P1/18; A61P5/14; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P27/16; A61P29/00; A61P37/06; C07C57/145; C07C57/15; C07C59/255; C07C65/05
Attorney, Agent or Firm:
Patent Attorney Corporation Asamura Patent Office