Title:
治療用化合物およびその使用
Document Type and Number:
Japanese Patent JP6820254
Kind Code:
B2
Abstract:
and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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Inventors:
Romero, F. Antony
Magnuson, Stephen Earl.
Pastor, richard
Tsui, Vicky Xiao-Way
Murray, Jeremy
Crawford, Terry
Burdick, Daniel Jay.
Albrecht, Brian Kay.
Coat, alexander
Taylor, Alexander M.
Nasveschak, Christopher Gee.
Leblanc, eve
Hewitt, Michael Charles
Rye
Chen, Kevin
Magnuson, Stephen Earl.
Pastor, richard
Tsui, Vicky Xiao-Way
Murray, Jeremy
Crawford, Terry
Burdick, Daniel Jay.
Albrecht, Brian Kay.
Coat, alexander
Taylor, Alexander M.
Nasveschak, Christopher Gee.
Leblanc, eve
Hewitt, Michael Charles
Rye
Chen, Kevin
Application Number:
JP2017518804A
Publication Date:
January 27, 2021
Filing Date:
October 10, 2015
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
C07D223/16; A61K31/55; A61K31/551; A61K31/553; A61K45/00; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/06; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/06; C07D243/12; C07D267/14; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/10; C07D403/14; C07D405/04; C07D405/12; C07D405/14; C07D413/04; C07D413/10; C07D413/12; C07D471/04; C07D495/04
Domestic Patent References:
| JP1203374A |
Foreign References:
| WO2006051851A1 | ||||
| WO2012151512A1 | ||||
| WO2014160873A1 | ||||
| US3203952 |
Other References:
Medicinal Chemistry Research,2013年,Vol.22(12),p.5739-5751
Zeitschrift fuer Naturforschung, B: Chemical Sciences,1995年,Vol.50(12),p.1869-1882
Computational & Theoretical Chemistry,2014年,Vol.1044,p.15-23
Tetrahedron Letters,2010年,Vol.51(38),p.4959-4961
Chemistry of Heterocyclic Compounds,2000年,No.6,p.799-805
Magnetic Resonance in Chemistry,1991年,Vol.29(3),p.244-247
Synthesis,1987年,Vol.8,p.724-726
Voprosy Khimii i Khimicheskoi Tekhnologii,1977年,Vol.46,p.12-17
RN:1553907-37-1,REGISTRY(STN),2014年 2月24日
RN:1599717-11-9、他計98化合物,REGISTRY(STN),2014年 5月 8日
Zeitschrift fuer Naturforschung, B: Chemical Sciences,1995年,Vol.50(12),p.1869-1882
Computational & Theoretical Chemistry,2014年,Vol.1044,p.15-23
Tetrahedron Letters,2010年,Vol.51(38),p.4959-4961
Chemistry of Heterocyclic Compounds,2000年,No.6,p.799-805
Magnetic Resonance in Chemistry,1991年,Vol.29(3),p.244-247
Synthesis,1987年,Vol.8,p.724-726
Voprosy Khimii i Khimicheskoi Tekhnologii,1977年,Vol.46,p.12-17
RN:1553907-37-1,REGISTRY(STN),2014年 2月24日
RN:1599717-11-9、他計98化合物,REGISTRY(STN),2014年 5月 8日
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita