Title:
THERAPEUTIC MICROVESICLE AND STEM CELL SYNTHESIS
Document Type and Number:
Japanese Patent JP2019201631
Kind Code:
A
Abstract:
To provide stem cell and exosome compositions having therapeutic utility to treat a variety of diseases and disorders, e.g., cardiovascular disease, Duchenne muscular dystrophy, and fibrotic disease.SOLUTION: The invention provides an exosome or microvesicle selected from an iPSC cell, an embryonic stem cell, and a stem cell that has been contacted with an effective amount of an isoxazole compound, a derivative or equivalent thereof or Danazol, where the exosome or microvesicle overexpresses one or more of: a specific microRNA (miRNA); and/or one or more proteins selected from among Tsg101, CD9, Hsp70, Flotillin-1 and GAPDH.SELECTED DRAWING: None
Inventors:
MUHAMMAD ASHRAF
Application Number:
JP2019011767A
Publication Date:
November 28, 2019
Filing Date:
January 28, 2019
Export Citation:
Assignee:
MUHAMMAD ASHRAF
International Classes:
C12N5/0735; A61K31/58; A61K31/7105; A61K35/12; A61K35/15; A61K35/34; A61K35/44; A61K35/545; A61K45/00; A61K48/00; A61P3/10; A61P5/00; A61P7/00; A61P7/06; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P15/00; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/02; A61P25/16; A61P25/18; A61P25/28; A61P27/16; A61P29/00; A61P39/06; A61P43/00; B82Y5/00; B82Y40/00; C12N5/071; C12N5/077; C12N5/0775; C12N5/10
Domestic Patent References:
| JP2017513482A | 2017-06-01 |
Other References:
STEM CELLS INTERNATIONAL, vol. Vol.2017, Article ID 5785436, JPN7023000709, 15 October 2017 (2017-10-15), pages 1 - 14, ISSN: 0004992036
Attorney, Agent or Firm:
Masataka Tanaka