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Title:
THERAPEUTIC NUCLEOSIDE COMPOUND AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH11343292
Kind Code:
A
Abstract:

To obtain the subject compound having advantageous antiviral activity, especially viral activity advantageous for infection with human immunological deficiency virus and hepatitis type B virus and low cytotoxicity, by not substantially including an enantiomer corresponding to a specific nucleoside compound.

This compound is (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H- purin-9-yl]-2-cyclopentene-1-methanol containing <10% w/w of a corresponding enantiomer and substantially not containing the corresponding enantiomer. As a preferable production method, the compound is obtained by treating an enantiomer compound of the formula [A is cyclopentene-1-methanol-yl of (1S,4R) configuration; Z is a precursor of a group R showing cyclopropylamino or the like] with a reagent to convert the precursor group Z into the fixed group R or under conditions.


Inventors:
DALUGE SUSAN MARY
Application Number:
JP12618599A
Publication Date:
December 14, 1999
Filing Date:
May 06, 1999
Export Citation:
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Assignee:
WELLCOME FOUND
International Classes:
A61K31/00; A61K31/505; A61K31/52; A61P31/00; A61P31/12; C07H19/16; A61P31/18; A61P31/20; A61P37/00; A61P37/04; C07C215/42; C07C215/44; C07D239/22; C07D239/42; C07D239/46; C07D239/48; C07D239/50; C07D473/00; C07D473/16; C07D473/18; C07D473/32; C07D473/40; C07F9/6561; (IPC1-7): C07D473/16; A61K31/00; A61K31/52; C07D239/50
Attorney, Agent or Firm:
Akira Asamura (3 outside)