NEW MATERIAL: A compound (a salt) represented by formula I, wherein R denotes H, CN, formula II (wherein R1 denotes a 1-6C alkyl, a cyano-1-6C alkyl or a pyridyl-1-6C alkyl), etc.; and R2 denotes H or a hydroxy protecting group.
EXAMPLE: 1,3,4-Thiadiazol-2-ylcyanamide-3-β-D-ribofuranose.
USE: A therapeutic agent for viral infection.
PROCESS: A solution of β-D-ribofuranose compound (such as β-D- ribofuranose-1,2,3,5-tetraacetate, etc.), is added to a solution where dry HBr is saturated in dry methylene chloride, and the like for reaction to obtain a derivative represented by formula III (wherein X denotes an eliminable group). Then, it is reacted with 2-amino-1,3,4-thiadiazole represented by formula IV (wherein R3 denotes H; and R denotes H, cyano, etc.), and optionally deprotected to obtain a compound represented by formula I.
UEIN ARUFURETSUDO SUPITSUTSUAA
FURANTSU BIKUTAA
