Title:
THIAZOLE DERIVATIVE HAVING CB1-ANTAGONISTIC, AGONISTIC OR PARTIAL AGONISTIC ACTIVITY
Document Type and Number:
Japanese Patent JP2011105734
Kind Code:
A
Abstract:
To provide a thiazole derivative which is a powerful cannabinoid (CB1) receptor antagonist, a powerful cannabinoid (CB1) receptor agonist or a powerful cannabinoid (CB1) receptor partial agonist and exhibits benefits for treating psychiatric disorders, neurological disorders, and other diseases relating to cannabinoid CB1 neurotransmission.
The thiazole derivative is represented by formula (1), wherein R is a halogen atom and each of R1 to R4 is a specified substituent.
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Inventors:
LANGE JOSEPHUS H M
KRUSE CORNELIS G
HERREMANS ARNOLDUS H J
VAN STUIVENBERG HERMAN H
DIJKSMAN JESSICA A R
MCCREARY ANDREW C
KRUSE CORNELIS G
HERREMANS ARNOLDUS H J
VAN STUIVENBERG HERMAN H
DIJKSMAN JESSICA A R
MCCREARY ANDREW C
Application Number:
JP2011003135A
Publication Date:
June 02, 2011
Filing Date:
January 11, 2011
Export Citation:
Assignee:
ABBOTT HEALTHCARE PRODUCTS BV
International Classes:
C07D277/20; A61K31/425; A61K31/426; A61K31/427; A61K31/454; A61K31/5377; A61K31/55; A61P1/00; A61P1/04; A61P1/08; A61P1/12; A61P1/14; A61P3/04; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P11/08; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/36; A61P27/02; A61P27/06; A61P31/04; A61P31/12; A61P35/00; A61P39/02; A61P41/00; A61P43/00; C07D277/56; C07D277/68; C07D417/12
Attorney, Agent or Firm:
Patent business corporation Odashima patent office