Title:
THIAZOLIDINE COMPOUND AND GLYCATION INHIBITOR CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPH03261772
Kind Code:
A
Abstract:
NEW MATERIAL:A compound of formula I (n is 2-4).
EXAMPLE: 2(RS)-5,5-Dimethyl-D-galacto-(1',2',3',4',5'-pentahydroxypentyl) thiazohidine-4-(S)-carboxylic acid.
USE: A glycation-inhibiting agent. Useful for treating arterial sclerosis accompanied with diabetic cataract or aging, etc. The compound of formula I has an extremely strong glycation-inhibiting activity and a little adverse action.
PREPARATION: An aldose of formula II and penicillamine of formula III are heated and refluxed in the presence of a base (e.g. pyridine) in a solvent such as methanol for 1-10 hours to provide the compound of formula I.
Inventors:
SUMOTO KUNIHIRO
MIYANO SEIJI
TATSUOKA TOSHIO
KISO YOSHINOBU
MIYANO SEIJI
TATSUOKA TOSHIO
KISO YOSHINOBU
Application Number:
JP5949090A
Publication Date:
November 21, 1991
Filing Date:
March 09, 1990
Export Citation:
Assignee:
SUNTORY LTD
International Classes:
C07D277/06; A61K31/425; A61K31/426; A61K31/70; A61P3/08; A61P3/10; A61P9/10; A61P27/02; A61P27/12; C07H9/06; (IPC1-7): A61K31/425; A61K31/70; C07D277/06; C07H9/06
Attorney, Agent or Firm:
Miyuki Ariga (2 outside)