チアゾリジンジオン誘導体および抗糖尿病薬としてのその使用

Title:

チアゾリジンジオン誘導体および抗糖尿病薬としてのその使用

Document Type and Number:

Japanese Patent JP4283449

Kind Code:

B2

Abstract:

5-(4-(2-(N-Methyl-N-(2-pyridyl) amino)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride dihydrate (I), characterized by its infra-red and x-ray diffraction spectra is new. 5-(4-(2-(N-Methyl-N -(2-pyridyl)amino)ethoxy)benzyl) thiazolidine-2,4-dione (I) hydrochloride dihydrate, characterized by infra-red spectrum peaks at 3392, 2739, 1751, 1325, and 713 wavenumbers, and x-ray powder diffraction pattern (XRPD) peaks at 9.1, 12.0, 15.7, 16.3, and 19.8 degrees 2-theta , including isolated, pure, and crystalline forms, is new. An independent claim is also included for the preparation of the hydrochloride dihydrate salt (Ia), by treatment of (I) with a suitable source of chloride counter ion and appropriate amounts of water, followed by recovery of the product. ACTIVITY : Antidiabetic; nephrotropic; hypoglycemic; hypolipidemic; hypotensive; antiarteriosclerotic; anabolic; anorectic.

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Inventors:

Paul David James Blackler
Robert Gordon Giles
Michael john sus

Application Number:

JP2000612295A

Publication Date:

June 24, 2009

Filing Date:

April 19, 2000

Export Citation:

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Assignee:

SmithKline Beecham p.l.c.

International Classes:

C07D417/12; A61K31/4402; A61K31/4439; A61P3/10; C07D417/00; A61K31/00

Domestic Patent References:

JP1131169A
JP8501095A
JP7503129A

Foreign References:

WO1999031093A1

Other References:

J.Chem.Soc.Perkin Trans. 1,1994年,Vol.22,p.3319-3324

Attorney, Agent or Firm:

Aoyama Aoi
Mitsuo Tanaka

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