Title:
チオフェンおよびベンゾチオフェンヒドロキサム酸誘導体
Document Type and Number:
Japanese Patent JP2007508318
Kind Code:
A
Abstract:
The present invention relates to a novel class of hydroxamic acid derivatives having a benzothiophene or thiophene backbone. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit historic deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases, The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.
Inventors:
Mirror Thomas A.
Witter David J.
Belvedere Sandro
Witter David J.
Belvedere Sandro
Application Number:
JP2006534428A
Publication Date:
April 05, 2007
Filing Date:
October 08, 2004
Export Citation:
Assignee:
Aton Pharma Inc.
International Classes:
C07D333/34; A61K31/381; A61K31/4045; A61K31/4184; A61K31/427; A61K31/4436; A61K31/4535; A61K31/4709; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; A61K31/551; A61P1/04; A61P1/14; A61P1/16; A61P1/18; A61P3/00; A61P3/10; A61P5/14; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P15/06; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P35/02; A61P35/04; A61P37/00; A61P37/08; A61P39/00; A61P41/00; A61P43/00; C07D333/36; C07D333/38; C07D333/70; C07D333/72; C07D409/12; C07D417/12; A61K
Domestic Patent References:
| JP2003514904A | 2003-04-22 | |||
| JPS60209577A | 1985-10-22 | |||
| JP2005539001A | 2005-12-22 | |||
| JPH10195065A | 1998-07-28 |
Foreign References:
| US20030013757A1 | 2003-01-16 | |||
| WO2002074298A1 | 2002-09-26 | |||
| WO2004013130A1 | 2004-02-12 | |||
| WO2005066151A2 | 2005-07-21 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi