Title:
THIOUREA DERIVATIVE OF PLAUNOTOL
Document Type and Number:
Japanese Patent JPH09165368
Kind Code:
A
Abstract:
To obtain thiourea derivative of plaunotol having excellent antiulcer action and antibacterial action against Hericobacter pyroli and useful for therapy and/or prevention of ulcerative disease.
This compound is a thiourea derivative of plaunotol or its pharmacologically permissible salt of formula I [R1 and R2 are each hydroxyl, amino, a group of the formula, NH-CS-NH-X-R3 (R3 is a 1-6C alkyl, a 3-10C cycloalkyl, etc.; X is a single bond, a 1-6C alkene), etc.; (n) is an integer of 0-2], e.g. plaunotol-1-ethylthiourea. The compound of formula I is obtained by e.g. reacting a compound of formula II with a compound of formula III (R5 is a 1-6C alkyl, etc.) in an inert solvent in the presence of 6-10C triarylphosphine (preferably triphenylphosphine), etc.
Inventors:
AKIYAMA TOSHIYUKI
KADOKAWA HIROSHI
UTSUI YUKIO
KOGA TETSUFUMI
TABATA KEIICHI
Application Number:
JP32666795A
Publication Date:
June 24, 1997
Filing Date:
December 15, 1995
International Classes:
C07D333/20; A61K31/17; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/4035; A61K31/42; A61K31/421; A61K31/44; A61K31/4412; A61K31/4418; A61P1/04; A61P31/04; C07C335/10; C07D209/48; C07D213/40; C07D261/06; C07D261/08; C07D261/14; C07D263/30; C07D263/32; C07D263/48; C07D275/02; C07D277/28; C07D307/14; (IPC1-7): C07C335/10; A61K31/17; A61K31/38; A61K31/40; A61K31/42; A61K31/44; C07D209/48; C07D213/40; C07D261/06; C07D261/08; C07D261/14; C07D263/30; C07D263/32; C07D263/48; C07D275/02; C07D277/28; C07D307/14; C07D333/20
Attorney, Agent or Firm:
Akio Ohno (2 outside)
