【発明の名称】三環式化合物およびその中間体

Title:

【発明の名称】三環式化合物およびその中間体

Document Type and Number:

Japanese Patent JPH0694464

Kind Code:

B2

Abstract:

Disclosed is a tricyclic compound represented by the formula (I): wherein each of R<1>, R<2>, R<3> and R<4> independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halogenated C1-6 alkoxy, halogen, nitro, cyano, carboxy, C1-6 alkoxycarbonyl, hydroxymethyl, CR<9>R<1><0>CO2R<1><1> (wherein each of R<9>, R<1><0> and R<1><1> independently represents hydrogen or C1-6 alkyl) or CONR<1><2>R<1><3> (wherein each of R<1><2> and R<1><3> independently represents hydrogen or C1-6 alkyl); R<5> represents hydrogen or C1-6 alkyl; each of R<6>, R<7> and R<8> independently represents hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkanoyloxy, C1-6 alkylthio, thiocyanato or halogen; X represents CH or N; Y<1>-Y<2> represents CH2-O, CH2-S(O)n, (wherein n represents 0, 1, or 2), CH2CH2, CH=CH or CON(R<1><4>) (wherein R<1><4> represents hydrogen or C1-6 alkyl) and Z represents oxygen or sulfur, or a pharmaceutically acceptable salt thereof. The compound possesses an acyl coenzyme A: cholesterol acyltransferase-inhibiting activity, and thus are expected to have preventive and therapeutic effects on hyperlipemia and arteriosclerosis.

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Inventors:

Toshiaki Kumazawa
Yanase Masashi
Harakawa Yoko
Hiroyuki Obase
Shoji Oda
Shirokura Shirokura
Yamada Koji
Kubo Kazuhiro

Application Number:

JP840692A

Publication Date:

November 24, 1994

Filing Date:

January 21, 1992

Export Citation:

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Assignee:

Kyowa Fermentation Industry Co., Ltd.

International Classes:

A61K31/165; A61K31/18; A61K31/19; A61K31/215; A61K31/235; A61K31/275; A61K31/38; A61K31/435; A61K31/44; A61K31/55; A61P3/06; A61P9/10; A61P43/00; C07C233/65; C07C235/46; C07C235/48; C07C237/40; C07C323/40; C07C323/62; C07C327/26; C07C331/08; C07D221/16; A61K31/335; C07D223/20; C07D233/58; C07D313/12; C07D337/12; C07D471/04; C07D491/04; C07D491/044; C07D495/04; (IPC1-7): C07D313/12; C07C235/46; C07C235/48; C07C237/40; C07C323/40; C07C323/62; C07C327/26; C07C331/08; C07D221/16; C07D223/20; C07D337/12; C07D471/04; C07D491/044; C07D495/04

Other References:

【文献】米国特許4489090(US,A)

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