Title:
タイトジャンクション調節剤
Document Type and Number:
Japanese Patent JP5429736
Kind Code:
B2
Abstract:
To provide a factor capable of inducing tricellulin acting on tight junction (TJ), a TJ modulator, and a medicine-delivery system employing the TJ modulator.
Tricellulin is detected on a site whereon a LSR (a lipolysis-stimulated receptor) is detected, and therefore a LSR is understood to be a factor capable of inducing tricellulin. Further, a substance interacting with a LSR, namely a substance suppressing the expression of a LSR gene or a substance inhibiting the function of a LSR can be a TJ modulator capable of modulating the function of TJ via tricellulin. The medicine-delivery system includes the TJ modulator and a medicine.
COPYRIGHT: (C)2011,JPO&INPIT
Inventors:
Mikio Furuse
Sayuri Masuda
Sayuri Masuda
Application Number:
JP2009096976A
Publication Date:
February 26, 2014
Filing Date:
April 13, 2009
Export Citation:
Assignee:
National University Corporation Kobe University
International Classes:
C07K14/47; A61K31/7105; A61K38/00; A61K47/24; A61K47/42; A61K48/00; A61P43/00; C12N15/113; A61K9/06; A61K9/08; A61K9/10; A61K9/70
Domestic Patent References:
| JP2001512492A |
Other References:
J Biol Chem., 1999年, 第274巻, 13390-13398ページ
Eur J Biochem., 2004年, 第271巻, 3103-3114ページ
J Cell Sci., 2011年, 第124巻, 548-555ページ
上原記念生命科学財団研究報告集, 2009年, 第23巻, RONBUNNO.70
Eur J Biochem., 2004年, 第271巻, 3103-3114ページ
J Cell Sci., 2011年, 第124巻, 548-555ページ
上原記念生命科学財団研究報告集, 2009年, 第23巻, RONBUNNO.70
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Yuriko Shinobu
Takuya Osugi
Aki Soga