Title:
TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
Document Type and Number:
Japanese Patent JP2022084623
Kind Code:
A
Abstract:
To provide antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit activity thereof, where such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.SOLUTION: The invention provides an isolated antibody, or antigen-binding fragment thereof, that specifically binds to an epitope in Kunitz Domain 2 (K2) of the Tissue Factor Pathway Inhibitor (TFPI).SELECTED DRAWING: Figure 4
Inventors:
JAMES R APGAR
SUSAN BENARD
GREGORY J CARVEN
SUNITA R HETT
MATTHEW HOLSTI
REEMA JASUJA
MACY JIN
JUO ZONG SEAN
DEBRA PITTMAN
MARK STAHL
SUSAN BENARD
GREGORY J CARVEN
SUNITA R HETT
MATTHEW HOLSTI
REEMA JASUJA
MACY JIN
JUO ZONG SEAN
DEBRA PITTMAN
MARK STAHL
Application Number:
JP2022026738A
Publication Date:
June 07, 2022
Filing Date:
February 24, 2022
Export Citation:
Assignee:
PFIZER
International Classes:
C12N15/13; A61K31/195; A61K38/36; A61K38/37; A61K39/395; A61K45/00; A61P7/04; A61P43/00; C07K14/745; C07K16/36
Domestic Patent References:
| JP2014511685A | 2014-05-19 | |||
| JP2012513377A | 2012-06-14 |
Foreign References:
| WO2014140240A1 | 2014-09-18 |
Attorney, Agent or Firm:
Nozomi Shimoto
Maki Sato
Miyuki Tatsuda
Ria Ikeda
Maki Sato
Miyuki Tatsuda
Ria Ikeda
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