Title:
【発明の名称】抗腫瘍活性をもつ1,2‐ジアミノシクロヘキサン‐プラチナ錯体
Document Type and Number:
Japanese Patent JPH02500745
Kind Code:
A
Abstract:
The invention relates to a process for the treatment of tumors in animals with water soluble square-planar cis platinum(II) four-coordinate complexes comprising different nonovalent and divalent organic cations. Monovalent cations include galacturonato and N,N-dimethylglycinato and divalent cations include citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, isopropyl, n-butyl, secbutyl, ter-butyl, n-amyl, isoamyl or -OH. The treatment of animals comprises administering to the animals a pharmaceutical composition comprising a platinum complex of the composition described.
Inventors:
Coker Abdul Earl
Newman Robert A
Krakow Irwin H
Newman Robert A
Krakow Irwin H
Application Number:
JP50030688A
Publication Date:
March 15, 1990
Filing Date:
November 16, 1987
Export Citation:
Assignee:
Board of Regents The University of Texas System
International Classes:
A61K33/24; A61P35/00; C07C211/65; C07C229/16; C07C239/18; C07D307/24; C07F15/00; C07H7/033; A61K31/28; C07H23/00; (IPC1-7): A61K31/28; A61K33/24; C07C211/65; C07C229/16; C07C239/18; C07D307/24; C07F15/00; C07H7/033
Foreign References:
| US4355964A | 1982-10-26 | |||
| US4231726A | 1980-11-04 | |||
| US3781149A | 1973-12-25 | |||
| US3276387A | 1966-10-04 | |||
| US3251309A | 1966-05-17 |
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)