【発明の名称】〔1-オキソ-2-アリ-ルまたはチエニル-2-置換-5-インダニルオキシ(またはチオ)〕アルカン酸の製法

Japanese Patent JPS5939415

B2

1474460 Indanones MERCK & CO Inc 7 Oct 1974 [11 Oct 1973 30 July 1974] 26849/76 Divided out of 1474459 Heading C2C The invention comprises compounds of formula wherein R‹ is (a) Ph optionally substituted by NO 2 , OH, C 1-5 alkyl or alkoxy, cycloalkyl, halogen, NH 2 , CN, SO 2 , NH 2 , SO 2 Me or SO 2 Cl, or (b) thienyl optionally substituted by C 1-5 alkyl and/or halogen; R* is H, C 1-5 alkyl or aralkyl; A is O or S; R is (up to C 5 ) alkyl or alkenyl, Ph-C 1-3 alkyl, Ph-C 3-5 alkenyl, aryl (possibly substituted), cycloalkyl or cycloalkyl-C 1-5 alkyl, and R1 is H, C 1-5 alkyl or aryl, or R-R1 is a C 1-4 bivalent hydrocarbon chain; X1 is H, Z or Me and X2 is Z, Me or CZ 3 (where Z = halogen), or X1-X2 is a C 3-4 bivalent hydrocarbon chain. In examples, these compounds are prepared by (i) introducing the substituent R‹ or R, (ii) converting the compound where R*A is MeO to the corresponding phenol, or (iii) introducing a CN or NO 2 group into the Ph ring represented by R‹. Details are given for the preparation of 2,21-dithienyl iodonium chloride and its substituted analogues. It is stated that certain compounds of the invention have diuretic, saluretic and uricosuic activity.

EDOWAADO JEE KURAGOO JUNYA
OTSUTOO DABURYU UORUTAASUDORUFU JUNYA

JP11698774A

September 22, 1984

October 11, 1974

Click for automatic bibliography generation  

MERCK & CO INC

C07C69/708; A61K31/12; A61K31/165; A61K31/19; A61K31/192; A61K31/195; A61K31/22; A61K31/38; A61K31/381; A61K31/495; A61K31/585; A61P7/10; C07C13/465; C07C45/46; C07C45/63; C07C45/65; C07C45/67; C07C45/68; C07C45/71; C07C49/613; C07C49/747; C07C49/755; C07C49/84; C07C51/00; C07C51/487; C07C59/125; C07C59/66; C07C59/68; C07C59/70; C07C59/86; C07C59/88; C07C59/90; C07C63/337; C07C67/00; C07C69/712; C07C201/00; C07C205/45; C07C225/22; C07C231/00; C07C231/02; C07C235/20; C07C235/30; C07C253/00; C07C255/13; C07C255/56; C07C301/00; C07C303/40; C07C311/16; C07C313/00; C07C315/04; C07C317/24; C07C319/14; C07C323/52; C07C333/18; C07D241/26; C07D257/04; C07D331/04; C07D333/04; C07D333/06; C07D333/18; C07D333/22; C07D333/26; C07D409/12; C07D475/08; (IPC1-7): C07C59/66; C07C51/08; C07C51/09; C07C51/367; C07C51/38; C07C79/36; C07C97/10; C07C121/76; C07C143/78; C07C147/06; C07D333/22

Masao Okabe

Previous Patent: Water-borne-adhesive constituent

Next Patent: CONTINUOUS EXTRUSION DEVICE OF STEEL MATERIAL