Title:
【発明の名称】2-(5-フルオロニコチノイル)酢酸誘導体およびその塩
Document Type and Number:
Japanese Patent JPH0629246
Kind Code:
B2
Abstract:
NEW MATERIAL:The 2-(5-fluoronicotinoyl)acetic acid derivative of formula I (R<1> is group capable of forming carboxyl-protecting group; R<2> is halogen, hydroxy, 3-aminopyrrolidinyl, piperazinyl, alkoxy, alkylthio, arylthio, alkanesulfonyloxy, or arenesulfonyloxy; X is H or F) and its salt. EXAMPLE:2-(2,4-Difluorophenylamino)-5-fluoro-6-hyroxynicotinoylacetic acid ethyl ester. USE:Intermediate for 1-aryl-1,4-dihydro-4-oxonaphthyridine derivative exhibiting strong bactericidal effect against Gram-positive bacteria and Gram-negative bacteria, and its salt. PREPARATION:The compound of formula I can be produced e.g. by reacting the reactive derivative of the compound of formula II at the carboxyl group with the compound of formula III or its salt.
Inventors:
TODO YOZO
SANTO TETSUO
NAGUMO KATSUYUKI
KITAYAMA ISAO
NAGAKI HIDEYOSHI
SHINAGAWA MIKAKO
KONISHI YOSHINORI
NARITA HIROKAZU
TAKANO SHUNTARO
SAIKAWA ISAMU
SANTO TETSUO
NAGUMO KATSUYUKI
KITAYAMA ISAO
NAGAKI HIDEYOSHI
SHINAGAWA MIKAKO
KONISHI YOSHINORI
NARITA HIROKAZU
TAKANO SHUNTARO
SAIKAWA ISAMU
Application Number:
JP2839785A
Publication Date:
April 20, 1994
Filing Date:
February 18, 1985
Export Citation:
Assignee:
TOYAMA CHEMICAL CO LTD
International Classes:
C07C257/14; C07D207/00; C07D213/00; C07D213/74; C07D213/78; C07D401/04; C07D401/12; C07D471/04; (IPC1-7): C07D213/74; C07D401/04
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