Title:
【発明の名称】20-メチル-置換ビタミンD-誘導体
Document Type and Number:
Japanese Patent JP3280975
Kind Code:
B2
Abstract:
New 20-methyl-substituted vitamin D derivatives of general formula I (I) are described in which R1 means a hydrogen atom, a hydroxy group or an alkanoyloxy group with 1 to 12 carbon atoms or a benzoyloxy group, R2 means a hydrogen atom or an alkanoyl group with 1 to 12 carbon atoms or a benzoyl group and R3 means a saturated or unsaturated, straight-chain or branched hydrocarbon radical with up to 18 C atoms, which optionally contains carbocyclic structures, optionally substituted with one or more hydroxy, oxo, amino group(s) and/or one or more halogen atom(s) as well as optionally exhibits one or more oxygen, sulfur and/or nitrogen atom(s) as a bridging link or links in the hydrocarbon radical, and a process for their production. Relative to calcitriol, the new compounds exhibit a greatly improved induction of cell differentiation (HL-60) and are suitable for the production of pharmaceutical agents.
Inventors:
Nef, Gunter
Steinmeier, Andreas
Kirsch, Geralt
Schwarz, Kachika
Chilov-Eckert, Roots
Vidinker, Herbert
Harvey, Martin
Steinmeier, Andreas
Kirsch, Geralt
Schwarz, Kachika
Chilov-Eckert, Roots
Vidinker, Herbert
Harvey, Martin
Application Number:
JP51062193A
Publication Date:
May 13, 2002
Filing Date:
December 14, 1992
Export Citation:
Assignee:
Schering Actien Gezel Shaft
International Classes:
A61K31/59; A61P3/02; A61P3/14; A61P17/00; A61P35/02; A61P37/00; A61P43/00; C07C401/00; (IPC1-7): C07C401/00; A61K31/59; A61P3/02; A61P17/00; A61P35/02; A61P37/00; A61P43/00
Attorney, Agent or Firm:
Toshio Yano (3 outside)