Title:
【発明の名称】23,23-ジフルオロ-25-ヒドロキシ-ビタミンD↓3及びその調整方法
Document Type and Number:
Japanese Patent JPS60502152
Kind Code:
A
Abstract:
The invention provides a new derivative of vitamin D, 23,23-difluoro-25-hydroxycholecalciferol, a method for preparing said compound and various new intermediates utilized in such process. The compound is characterized by vitamin D-like activity as evidenced by its ability to increase intestinal calcium transport and serum calcium. It is further characterized by its resistance to hydroxylation at C-23, which is recognized as an essential metabolic step to the inactivation of vitamin D, and therefore should provide vitamin D-like activity of greater time duration.
Inventors:
Deluca, Hector F
Yoko Tanaka
Nobuo Ikegawa
Yoshio Kobayashi
Yoko Tanaka
Nobuo Ikegawa
Yoshio Kobayashi
Application Number:
JP50240084A
Publication Date:
December 12, 1985
Filing Date:
June 13, 1984
Export Citation:
Assignee:
Wisconsin Alumni Lisa-Chifonde-Syon
International Classes:
C07J1/00; C07C67/00; C07C401/00; C07J9/00; C07J17/00; C07J31/00; C07J51/00; C07J53/00; (IPC1-7): A61K31/59; C07C172/00; C07J17/00; C07J53/00
Attorney, Agent or Firm:
Takao Kawasaki