Title:
【発明の名称】炎症性および免疫性疾患の治療のための2,5‐ジアリールテトラヒドロ‐チオフェン、‐フランおよび類似体
Document Type and Number:
Japanese Patent JPH08502243
Kind Code:
A
Abstract:
2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. The compounds exhibit this biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by exhibiting dual activity, i. e., by acting as both a PAF receptor antagonist and inhibitor of 5-lipoxygenase.A method to treat disorders mediated by PAF or leukotrienes is also disclosed, that includes administering an effective amount of one or more of the above-identified compounds or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
Inventors:
Kai, Shon
Han, San-bao
Cillian, David
Shen, Tee. Wai.
Sijato, fusoin
Han, San-bao
Cillian, David
Shen, Tee. Wai.
Sijato, fusoin
Application Number:
JP50357294A
Publication Date:
March 12, 1996
Filing Date:
July 13, 1993
Export Citation:
Assignee:
SiteMed, Inc.
International Classes:
A61K31/17; A61K31/34; A61K31/341; A61K31/38; A61K31/381; A61P29/00; A61P37/00; A61P43/00; C07C291/02; C07D207/09; C07D307/12; C07D307/14; C07D333/06; C07D333/16; C07D333/18; C07D333/20; C07D405/04; C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D409/14; (IPC1-7): C07C291/02; C07D409/14; C07D409/12; C07D407/12; C07D405/14; C07D405/12; C07D333/06; C07D307/14; A61K31/38; A61K31/34; A61K31/17
Attorney, Agent or Firm:
Shusaku Yamamoto