Title:
【発明の名称】3 - ( 17 ベ-タ- - ヒドロキシ - 4 - アンドロステン - 3 - オン - 17 アルフア - イル ) - プロピオラクトンノセイホウ
Document Type and Number:
Japanese Patent JPS5821640
Kind Code:
B2
Abstract:
4-Androstene-3,17-dione and 1,4-androstadiene-3,17-dione are converted to 3-(17 beta -hydroxy-4-androsten-3-on-17 alpha -yl)-propionic acid lactone in three steps by reaction with propargyl alcohol in the presence of an alkali alcoholate of a tertiary alcohol, hydrogenating the thus-produced 17 alpha -(3-hydroxy-propinyl)-17- beta -hydroxy compound with hydrogen in the presence of a complex metallic catalyst to produce 17 alpha -(3-hydroxypropyl)-17 beta -hydroxy-3-keto-androst-4-ene, which is oxidized with chromic acid to the desired lactone.
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Inventors:
RAINERU FUIRITSUPUZON
Application Number:
JP5836574A
Publication Date:
May 02, 1983
Filing Date:
May 23, 1974
Export Citation:
Assignee:
SCHERING AG
International Classes:
C07J19/00; A61K31/565; A61K31/585; C07J1/00; C07J17/00; C07J21/00; A61K; C07C; C07J; (IPC1-7): C07J19/00
Attorney, Agent or Firm:
Toshio Yano