【発明の名称】3―アシロキシ―ビシクロ〔3.3.0〕オクタン―7―オン―2―カルボン酸エステルの立体特異性の酵素または微生物的アシレート加水分解によるラセミ分割

Japanese Patent JP2736066

B2

PCT No. PCT/DE87/00513 Sec. 371 Date Jul. 13, 1988 Sec. 102(e) Date Jul. 13, 1988 PCT Filed Nov. 12, 1987 PCT Pub. No. WO88/03567 PCT Pub. Date May 19, 1988.Process for the production of optically active (+)-bicyclo[3.3.0]octanol derivatives of formula (+)-I, in which R1 and R2represent jointly an oxygen atom or the double-bond residue -O-X-O- with X as a straight or branched-chain alkylene with 1-7 C-atoms, or R1 and R2 represent separately the residue OR5 with R5 as a straight or branched-chain alkyl with 1-7 C-atoms, and R3 the residue COOZ with Z as a hydrogen atom, straight or branched chain alkyl with 1-7 C atoms, cycloalkyl with 3-6 C atoms, phenyl or aralkyl with 7-10 atoms or R3 is the residue -(CH2)n-O-COR4 with n having the meaning 1-4 and R4 as a straight or branched-chain alkyl with 1-7 C atoms, cycloalkyl with 3-6 C atoms, phenyl or aralkyl with 7-10 C atoms. The process is characterized in that racemic 3 alpha -cyloxy-cis-bicyclo[3.3.0]-octane derivatives of formula (+)-II, wherein R1, R2R3 and R4 have the above meanings, are subjected enzymatically or microbiologically to a stereospecific acylate hydrolsis and the (+)-bicyclo[3.3.0]-octanol derivative produced is separated from the unsaponified bicyclo[3.3.0]-octanol acylate of formula (-)-II or the unsaponified enantiomers (+)-II are separated from the saponified bicyclo[3.3.0]octanol derivative (-)-I and then subjected to chemical acylate hydrolysis.

PETSUTSUORUTO KAARU
DAARU HERUMUUTO
SUKUBARA UERUNAA

JP50673787A

April 02, 1998

November 12, 1987

Click for automatic bibliography generation  

SHEERINGU AG

C07C247/00; C07C405/00; C07D317/72; C07D319/08; C12P7/26; C12P7/42; C12P7/62; C12P17/02; C12P41/00; C12P7/12; C12R1/01; C12R1/05; C12R1/15; C12R1/20; C12R1/785; C12R1/80; C12R1/84; C12R1/85; C12R1/865; C12R1/885; (IPC1-7): C12P41/00

Toshio Yano (1 outside)

Previous Patent: ガラス物品の製造用成形型等の表面潤滑法

Next Patent: 無線電話装置