Title:
【発明の名称】4‐アラルキル‐5‐置換‐1,2,4‐トリアゾール‐5‐チオール類
Document Type and Number:
Japanese Patent JPH03501731
Kind Code:
A
Abstract:
Compounds of formula (I) and pharmaceutically acceptable salts thereof are described in which, n is 0 to 5; X<1> to X<5> are any accessible combination of hydrogen, halogen, C1-6alkyl, C1-6alkoxy, cyano, nitro, SONH2, SO2NH2, SO2CH3, SO2CH2F, SO2CHF2, SO2CF3, CF3, CHO, OH, CH2OH, CO2H, or CO2CpH2p+1 wherein p is 1 to 4; R<1> is phenyl substituted by X<1> to X<5>, C1-4alkyl, C3-6cycloalkyl, or an arylC1-4alkyl group substituted by X<1> to X<5>; R<2> is hydrogen, C1-4alkyl or (CH2)m-CO2R<3>; m is 0 to 5; and R<3> is H or C1-4alkyl. These compounds are dopamine- beta -hydroxylase inhibitors. Pharmaceutical compositions are described as are methods of use. Processes for the preparation of these compounds are described.
Inventors:
Cruz, Lawrence Ivan
Finkelstein, Joseph Alan
Finkelstein, Joseph Alan
Application Number:
JP50159889A
Publication Date:
April 18, 1991
Filing Date:
December 21, 1988
Export Citation:
Assignee:
SmithKline Beckman Corporation
International Classes:
A61K31/41; A61P9/12; A61P43/00; C07C335/40; C07D249/12; (IPC1-7): C07D249/12; A61K31/41; C07C335/40
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)