Title:
【発明の名称】9‐ハロゲン‐(Z)‐プロスタグランジン誘導体、その製法及び薬剤としてのその使用
Document Type and Number:
Japanese Patent JP2716986
Kind Code:
B2
Abstract:
9-Halogen-(Z)-prostane derivatives have the formula (I), where Z is one of the residues (a) or (b), Hal is a chorine or fluorine atom in the alpha or beta position, R1 is the residue CH2OH or (c) where R2 is a hydrogen atom or an alkyl, cycloalkyl, aryl, or heterocyclic residue, or R1 is the residue (d) where R3 is an acid residue or the R2 residue, A is a -CH2-CH2-, a trans-CH=CH or a -C=C-group, W is a free or functionally modified hydroxymethylene group or a free or functionally modified (e) group, in which the corresponding OH groups can be in the alpha or beta position, D and E together represent a direct bond or D is a straight-chain alkylene group with 1-10 C-atoms, a branched-chain alkylene group with 2-10 C-atoms, or a cyclic alkylene group with 3-10 C-atoms, which may, if necessary, be substituted by fluorine atoms, and E is an oxygen or sulphur atom, a direct bond, a -C=C- bond, or a -CR6=CR7-group, where R6 and R7 are different and stand for a hydrogen atom, a chlorine atom, or a C1-C4 alkyl group, R4 is a free or functionally modified hydroxy group, R5 is a hydrogen atom, an alkyl group, a halogen-substituted alkyl group, a cycloalkyl group, a heterocyclic or possibly aryl-substituted group. The invention also concerns the salts of these derivatives with physiologically innocuous bases and their cyclodextrin chlathrates, in the case in which R2 is a hydrogen atom. Also described are the process for manufacturing these derivatives and their pharmaceutical use.
Inventors:
Buchmann, Bernd
Suvarra, Werner
Huaburiyutsugen, Helmut
Rade Uchel, Bernd
Olog
Elgar, Walter
Klaus-Syuttehuen, Syuteyurtz Ebecher
Karl Heinz, Teilaluf
Suvarra, Werner
Huaburiyutsugen, Helmut
Rade Uchel, Bernd
Olog
Elgar, Walter
Klaus-Syuttehuen, Syuteyurtz Ebecher
Karl Heinz, Teilaluf
Application Number:
JP50599288A
Publication Date:
February 18, 1998
Filing Date:
July 15, 1988
Export Citation:
Assignee:
Schering Actien Gezershaft
International Classes:
A61K31/557; A61K31/5575; A61P43/00; C07C29/62; C07C35/48; C07C43/178; C07C57/03; C07C59/62; C07C69/732; C07C69/734; C07C235/30; C07C235/40; C07C405/00; (IPC1-7): C07C35/48; C07C29/62; C07C43/178; C07C57/03; C07C59/62; C07C69/732; C07C69/734; C07C235/30; C07C235/40; C07C405/00
Attorney, Agent or Firm:
Toshio Yano (1 outside)